Start Date: 01/04/2019 End Date: 31/03/2023
Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Therefore, and considering the very limited regeneration ability of the central nervous system, in this project we propose to develop a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM) supported in a protein-rich decellularized matrix (adECM). In fact, the suggested 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells. Progress in this sense will contribute to a better understanding of the key factors controlling repair in damaged neural tissues and, consequently, bring insights into new therapeutic approaches for spinal cord recovery.
NeuroStimSpinal aims at developing a treatment for patients after spinal cord injury (SCI). SCI results in para- and tetraplegia caused by the partial or complete disruption of descending motor and ascending sensory neurons. It leads to devastating consequences such as sensory loss, paralysis and bowel/bladder dysfunctions. Different strategies have been proven at research level. However, today there is no effective SCI therapy that can entirely restore neuromotor deficits.
More information of the official website: https://www.neurostimspinal.eu/