NFFA-Europe Highlight: Live-Cell Imaging of a Metal-Free MRI Probe
Scientific Highlight within the framework of the NFFA-Europe project – Nonlinear Optical (NLO) microscopy demonstrates fluorescence emission from imaging probe in live cells.
The Institute of Materials Science of Barcelona (ICMAB-CSIC) in collaboration with the Stratakis Lab, ULMNP-FORTH demonstrated successful cellular internalization of a novel bimodal dendrimer-based probe with both magnetic and fluorescent properties, using nonlinear-optical (NLO) microscopy in living cells.
This innovative probe – developed for dual MRI and fluorescence imaging (FI) – uses organic radicals instead of metals, offering a safer, more sustainable alternative to conventional gadolinium-based contrast agents.
The work took advantage of the unique NLO-microscopy capabilities at ULMNP-FORTH, enabling minimally invasive live-cell imaging. This allowed the visualization of the probes inside living cells, at video rates.
Publication Details:
Y. Wu, V. Lloveras, A. Morgado, E. Perez-Inestrosa, E. Babaliari, S. Psilodimitrakopoulos, Y. Vida, and J. Vidal-Gancedo, ACS Applied Materials & Interfaces 2024 16 (47), 65295-65306. DOI: 10.1021/acsami.4c13578
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